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Hormones, Pregnancy, and JHS/EDS-hypermobility type

Posted By Alan Hakim, October 30, 2016

We have updated our website article on pregnancy and hypermobility to reflect the findings of two very recent publications that are important observations and of interest to patients, doctors and therapists.

In summary:

Sunderlin et al. identified 314 cases of pregnancy in women with either JHS or EDS through the Swedish Patient Register and Medical Birth Register. The cases were compared with 1,247,864 controls (pregnant women without JHS/EDS). The risk of complications in JHS/EDS was assessed after adjusting for maternal age, smoking, number of pregnancies, and year of birth. JHS/EDS was not associated with any increased risk of preterm birth, the need for a caesarean section, stillbirth, complications in the infant at delivery (a low Apgar score), or the infant being small or large for gestational age. At the same time similar observations have been published by Hugon-Rodin et al. This is reassuring. However there are other concerns that might arise, including musculoskeletal complications. To read our article on pregnancy and hypermobility in full click HERE.

Hugon-Rodin and colleagues also reported a high frequency of gynaecological complaints in JHS/EDS: menorrhagia (abnormally heavy bleeding) (76 %), dysmenorrhea (excessive pain during bleeding) (72 %) and dyspareunia (pain during sexual intercourse) (43 %); but endometriosis was not highly prevalent in this population. The researchers noted a subgroup of women were sensitive to hormonal fluctuations with more severe symptoms occurring during puberty, prior to menstruation, and during the postpartum (after childbirth) period. Many will likely not be surprised by these findings – but the paper is important as it highlights the reality that these are common concerns. To read more about hormones click HERE.


Hugon-Rodin J, Lebègue G, Becourt S, Hamonet C, Gompel A. Gynecologic symptoms and the influence on reproductive life in 386 women with hypermobility type ehlers-danlos syndrome: a cohort study. Orphanet J Rare Dis. 2016 Sep 13;11(1):124. doi: 10.1186/s13023-016-0511-2.

Sundelin HE, Stephasson O, Johansson K, Ludvigsson JF. Pregnancy outcome in Joint Hypermobility Syndrome and Ehlers Danlos Syndrome. Acta Obstet Gynecol Scand. 2016 Oct 14. doi: 10.1111/aogs.13043. [Epub ahead of print]

Dr Alan Hakim, Chief Medical Advisor and Trustee, HMSA. October 2016


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